Publications & Presentations

Stevens, L.E. High-Performance Dissolution: The Role of Convective-Diffusion and Controlled Hydrodynamics for Optimal Pharmaceutical Relevance.  Am. Pharm. Rev. 6(2):38-45 (2008).

Stevens, L.E. “Controlled Release Measurements for Ophthalmics using Controlled Hydrodynamics.”  FIP Dissolution / Drug Release Special Interest Group & The Royal Pharmaceutical Society of Great Britain, (London, England) Oct. 2008, invited speaker.

Stevens, L.E. Missel, P.J. and Weiner, A. L. “Controlled Flow-Through Release / Dissolution Methodology: A High Performance System”.  Pharm. Dev. Tech. 13:135-153 (2008).

Stevens, L.E. “High-Performance Dissolution: Improving Dissolution Measurements through Enhanced Understanding and Control of Hydrodynamics.”  International Institute of Research (Baltimore, MD) Mar. 2008; invited speaker, panel discussion, and conference chair. 

Stevens, L.E., Dissolution Techniques, Methods and In Vivo Correlations for Suspension Formulations, Alcon Research, Ltd., 2008, presentation.

Stevens, L.E. “Improving Dissolution Measurements with Enhanced Understanding and Control of Hydrodynamics.”  Informa Life Science, Dissolution Testing, Bioavailability & Bioequivalence, (Berlin, Germany) Nov. 2007, invited speaker.

Stevens, L.E. “Physicochemical and Bio-Relevance Through Controlled Hydrodynamics.”  PharmaEd Resources, Inc., (Philadelphia, PA) June 2007, invited speaker and co-chair.

Stevens, L.E. “Physicochemical and Bio-Relevance Through Controlled Hydrodynamics.”  United States Pharmacopeia, Research Consortium (Washington, DC) June 2007, invited speaker.

Stevens, L.E. and Missel, P.J. “Physicochemical and Bio-Relevance Through Controlled Hydrodynamics.”  International Institute of Research (Baltimore, MD) Mar. 2007; invited speaker; conference co-chair.

Stevens, L.E., Quality by Design and Regulatory Compliance for Dissolution Testing, Alcon Research, Ltd., 2007, presentation.

Stevens, L.E. and Missel, P.J.  Impact of Density Gradients on Flow-Through Dissolution in a Cylindrical Flow Cell.  Pharm. Dev. Tech. 11:529-534 (2006).

Missel, P.J., Stevens, L.E., Chastain, J. and Yaacobi, Y.  A Clear Vision for Drug Delivery.  Fluent News, XV (3):s8-s10 (2006).

Stevens, L. E.  Dissolution: Instrument Qualification, Automation and Calibration.  Tablets & Capsule Conference (Edison, NJ) Oct. 11, 2006; invited speaker: workshop panelist.

Stevens, L.E.  Methodologies for Novel Dosage Forms.  Tablets & Capsule Conference (Edison, NJ) Oct. 10, 2006, invited speaker.

Missel, P.J., Stevens, L.E.  Adaptation of USP Types I and IV Dissolution Assays for Sparingly Soluble Compounds by Direct Eluent HPLC Analysis.  Pharm. Dev. Tech. 11:87-91 (2006).

Stevens, L.E.  Methodologies for Determining the Release Characteristics of Drugs from Novel and Combination Dosage Forms.  AAPS National Meeting, Nov. 2005, invited speaker.

Stevens, L.E., Kinetics and Dissolution Testing for Poorly Soluble Drug Delivery Systems, Alcon Research, Ltd., 2005, presentation.

Missel, P.J., Stevens, L.E. and Mauger, J. W.  Re-Examination of Convective Diffusion / Drug Dissolution in a Laminar Flow Channel:  Accurate Prediction of Dissolution Rate.   Pharm. Res. 21:2300 – 2306 (2004).

Missel, P.J., Stevens, L.E. and Mauger, J. W.  Dissolution of Anecortave Acetate in a Cylindrical Flow Cell:  Re-Evaluation of Convective Diffusion / Drug Dissolution for Sparingly Soluble Drugs.   Pharm. Dev. Tech. 9:453 – 459 (2004).

Stevens, L.E. and Missel, P.J.  Impact of Density Gradients on Flow-Through Dissolution in a Cylindrical Flow Cell.  AAPS National Meeting (Baltimore, MD) Nov. 2004, poster.

Missel, P.J., Stevens, L.E. and Mauger, J. W.  An Alternative Interpretation of the Concept of Intrinsic Dissolution in the Convective Diffusion / Dissolution Model.  AAPS National Meeting (Salt Lake City, UT) Oct. 2003, poster.

Missel, P.J. and Stevens, L.E.  Finite Element Simulation of the Impact of Density Gradients on Flow-Through Dissolution at Slow Flow Rates.  AAPS National Meeting (Salt Lake City, UT) Oct. 2003, poster.

Stevens, L.E., Software Design, Development and Validation for a Fully Automated Dissolution System, Alcon Research, Ltd., 2003, presentation.

Missel, P.J. and Stevens, L.E.  Adaptation of USP Types I and IV Dissolution Assays for Sparingly Soluble Compounds by Direct HPLC Analysis of Eluent.  AAPS National Meeting  (Toronto, Canada) Nov. 2002, poster.

Stevens, L.E., Validation of an Enterprise Instrumental and Data Processing Software System, Alcon Research, Ltd., 2001, presentation.

Missel, P. J., Stevens, L. E., Kabra, B.  Reducing Heterogeneity of an Ion-Sensitive Gelling Polysaccharide Using Salt-Temperature Fractionation.  ACS, 220th National Meeting, Aug. 2000, presentation.

Stevens, L.E., Drug Binding Strength and Capacity Determined using Frontal Chromatography, Alcon Laboratories, Inc., 1999, presentation.

Stevens, L.E., Mathematical Separation and Quantitative Analysis of Two Chromaphores using Spectral Deconvolution, Alcon Laboratories, Inc., 1998, presentation.

Stevens, L.E.  CRAS-HPLC: An In Vitro Pre-Corneal Model.  Waters Millennium Users Forum, Waters, 1997, invited presentation.

Stevens, L.E., Polymer Characterization of Heterogeneous Polysaccharide Gelling Systems using Size Exclusion Chromatography and Multiangle Light Scattering, Alcon Laboratories, Inc., 1996, presentation.

Stevens, L.E., Missel, P.J., Separation and Optimization of Heterogeneous Polysaccharide Gelling Systems, Alcon Laboratories, Inc., 1996, presentation.

Stevens, L.E., The Use of Spectral Shifts in the Local Electronic Environment for Spectroscopic Assay Development, Alcon Laboratories, Inc., 1995, presentation.

Stevens, L.E., Missel, P.J., Lang, J.C.  Drug Release Profiles of Ophthalmic Formulations. Instrumentation.  Pharmacy Digest, (April 1993).

Stevens, L.E., Missel, P.J., Lang, J.C.  Drug Release Profiles of Ophthalmic Formulations. I. Instrumentation.  Anal. Chem. 64:715-723 (1992).

Stevens, L.E., Measurement and Kinetics of Drug Degradation, Alcon Laboratories, 1991, presentation.

Stevens, L.E. and Eckardt, J.I.  Spectrophotometric Determination of Polyquaternium-1 with Trypan Blue by a Difference Procedure.  Analyst, 112:1619-1621 (1987).

Stevens, L.E., Radio-Chemical Methods for the Determination of Preservative Sorption in Soft and Hard Gas Permeable Contact Lens, Alcon Laboratories, Inc., 1987, presentation.

Stevens, L.E., Durrwachter, J.R., Helton, D.O.  Analysis of Chlorhexidine Sorption in Soft Contact Lens by Catalytic Oxidation of a 14C-Label and by HPLC.  ACS, Southwest Meeting, Nov. 1985, presentation.

Stevens, L.E., Durrwachter, J.R., Helton, D.O.  Analysis of Chlorhexidine Sorption in Soft Contact Lens by Catalytic Oxidation of a 14C-Label and by HPLC.  J. Pharm. Sci. 75:83-86 (1986).

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